Bacterial vaccine and recurrent infections

Recurrent infections are a widespread global health problem. Treatment, usually with antibiotics, can lead to the emergence of antibiotic and antimicrobial resistance, leading to infections that are more difficult to treat and increased mortality¹.

Respiratory infections in Spain account for more than 15% of consultations in primary care and are one of the most frequent causes of hospital admission². Antibiotic prophylaxis, the main strategy used, is not free of adverse effects and generates antimicrobial resistance³. When infections can no longer be treated with first-line antibiotics, it is necessary to use other products¹.

What do bacterial vaccine treatments offer us?

– They enhance immune response.

– They generate immunological memory.

– Activate innate immune cells⁵.

– They OFFER BROAD PROTECTION against the pathogen contained in the vaccine specifically and against other pathogens non-specifically⁶.

Bibliography:

1. Resistencia a los antimicrobianos. (2020). Recuperado 17 de junio de 2021 de https://www.who.int/es/news-room/fact-sheets/detail/antimicrobial-resistance
2. J. Cabello Rueda, F. Hernández Utrera (2009). Patrones de resistencia en patógenos respiratorios en España. Suplemento Neumosur Diciembre.
3. EAU Guidelines. Edn. presented at the EAU Annual Congress Milan, Italy 2023. ISBN 978-94-92671-19-6.
4. Sánchez-Ramón et al. (2018) Frontiers in inmunology.
5. Bindu S, Dandapat S, Manikandan R, Dinesh M, Subbaiyan A, Mani P, Dhawan M, Tiwari R, Bilal M, Emran TB, Mitra S, Rabaan AA, Mutair AA, Alawi ZA, Alhumaid S, Dhama K. Prophylactic and therapeutic insights into trained immunity: A renewed concept of innate immune memory. Hum Vaccin Immunother. 2022 Dec 31;18(1):2040238. doi: 10.1080/21645515.2022.2040238. Epub 2022 Mar 3. PMID: 35240935; PMCID: PMC9009931.
6. Sánchez-Ramón et al. (2018) Frontiers in inmunology.